To the Editor: Dr Andrade’s analysis of the Bacloville trial in a recent Clinical and Practical Psychopharmacology column, in which he concluded that “individualized treatment with high-dose baclofen (30-300 mg/d) may be a useful second-line approach in heavy drinkers” and that “baclofen may be particularly useful in patients with liver disease,” deserves comment.1įirst, Andrade failed to recall that the first pivotal trial of baclofen, ALPADIR (NCT01738282 320 patients, as with Bacloville), was negative (see Braillon et al2). * These criteria are for descriptive and educational purposes only, and not meant to be used as a means of diagnosis.Baclofen, a French Exception, Seriously Harms Alcohol Use Disorder Patients Without Benefit ![]() Source: Anxiety Disorders Association of America * These criteria are for descriptive and educational purposes only, and not meant to be used as a means of diagnosis. The level of fear a person experiences is usually inappropriate to the situation, and is even recognized by the sufferer as being irrational. often experience a feeling of intense fear not only when they are in the presence of that specific place or object, but also in anticipation of being in the presence of that place or object. Specific Phobias: People who suffer from specific phobias such as a fear of heights, elevators, spiders, etc. Reluctance or refusal to go to school and/or extracurricular activities is common due to the child’s fear of separation, and fear of harm to loved ones while they are apart. Common behaviors that can occur upon being separated include crying, clinging, panic, and worry. Separation Anxiety/School Refusal: Separation anxiety in children is characterized by feelings of excessive anxiety while away from their parent/caregiver, or while away from home. Symptoms can include, but are not limited to heart palpitations, blushing, extreme sweating, and dizziness. Social Anxiety Disorder (SAD) : SAD is characterized by experiencing extreme anxiety for fear of being judged by others, or behaving in a way that might cause embarrassment and/or ridicule when in a social setting. Symptoms can include, but are not limited to heart palpitations, chest pain/discomfort, sweating, trembling, tingling sensations, a choking feeling, fear of dying, fear of losing control, and illusory feelings. Panic Disorder: Panic disorder is characterized by severe attacks of panic in individuals that can make them feel like they are having a heart attack, or make them feel out of control for no apparent reason. These obsessions can lead an individual to perform rituals or routines (compulsions) such as washing hands repeatedly, or repeating phrases over and over to relieve the anxiety caused by the obsessive thoughts. Typical obsessions can include worrying about being contaminated, fears of behaving improperly, or even fears of acting violently. Obsessive-Compulsive Disorder (OCD) : In OCD, individuals are plagued by persistent, recurring thoughts (obsessions) that reflect exaggerated anxiety or fears. ![]() Symptoms can include, but are not limited to muscular aches, insomnia, abdominal pain/discomfort, dizziness, trembling, and irritability. In adults, the anxiety may result from issues regarding health, finances, career, or relationships. Generalized Anxiety Disorder (GAD) : GAD is characterized by excessive and unrealistic worry.
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