(elevated phosphorus but normal calcium levels), dystrophic includingĬalcinosis (normal serum calcium-phosphorus levels but damaged tissue), ![]() Metastatic (abnormal serum calcium-phosphorus levels), tumoral Soft-tissue calcifications may be classified into Universalis associated with SLE was made. Inflammatory infiltrate a final diagnosis of calcinosis cutis To SLE was considered, but a skin biopsy showed no significant A diagnosis of calcifying panniculitis owing The dermatologists confirmed that the skin lesions To be more widespread in the lower limbs than noted on the plain film Radiographs were confirmed to be in the subcutaneous tissue and found The soft tissue calcifications noted on the other Scan confirmed the findings noted on the chest radiograph and furtherĭemonstrated calcifications around the shoulder and in the breast andīack (Fig. Hands demonstrated widespread calcifications in the soft tissue and noĮvidence of arthropathy (Figs 2a and b). Her chest radiograph showed a right pleuralĮffusion with cardiomegaly (Fig. Normal but urine dipstix demonstrated proteinuria, and a renal biopsy Phosphate levels were within normal limits. Markers were in keeping with active disease. This, inĬombination with clinical findings, fulfilled the American RheumatismĪssociation criteria for a diagnosis of SLE. The rest of the physical examination wasĪntinuclear antibodies and double-stranded DNA antibodies. Had muscle weakness, was tender around most joints and demonstratedĮvidence of healed vasculitic lesions on both hands and feet. Lesions with palpable hard deposits in the soft tissue. She had a malar rash and widespread hyperpigmented skin Involving the small joints of her hands,elbows and knees withĪffected. Her current complaints were polyarthritis Months prior to the current referral with a diagnosis of pneumonia, butĬlaimed to have had no improvement with therapy and she continued toĬough and lose weight. She was again admitted to her local hospital 6 She had beenĭiagnosed at her local hospital 6 years previously but had not receivedĪny specialist care. Rheumatology clinic for management of known active SLE. Presenting with calcinosis cutis universalis, 6 years after being We describe the case of a 21-year-old woman 1 It is described predominantly in females and may manifest anytime from 6 months to 18 years after the diagnosis of SLE. In nature and nearly always localised (calcinosis cutis circumscripta)īut may infrequently occur as a generalised form referred to asĬalcinosis cutis universalis. 1Ĭalcinosis cutis associated with SLE is dystrophic 1, 2 A review of the literature reveals that, up to 2010, only 37 cases were reported in the English-language literature. Rarely described in systemic lupus erythematosus (SLE). Oesophageal dysfunction, sclerodactyly and telangiectasia) but is Scleroderma and CREST (calcinosis, Raynaud’s phenomenon, Variety of rheumatic conditions, particularly dermatomyositis, IntroductionĬalcinosis cutis is a well-known phenomenon in a Occurrence of calcinosis cutis universalis. ![]() Who presented to us with a 6-year history of SLE and the rare ![]() In patients with SLE, it tends to be localised (circumscripta) rather Calcinosis cutis universalis – a rare manifestation of systemic lupus erthyematosusį E Suleman, MB ChB, FC Rad (Diag), M Med Rad (Diag)ĭepartment of Radiology, University of Pretoriaĭepartment of Internal Medicine, University of PretoriaĬorresponding author: F Suleman AbstractĬalcinosis cutis (or skin and subcutaneousĬalcification) is a feature of a variety of rheumatic conditions (mostĬommonly dermatomyositis and scleroderma), but is rarely reported in
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